The house builder said the scheme offers a greater choice for buyers and competitive lending rates.
Nationwide will offer its Home Buyer mortgage product range for Help To Buy purchasers, with rates from just 2.54 per cent.
Under the Help To Buy scheme, the Government provides an equity share loan of up to 20 per cent of the purchase price, with the buyer paying a 5 per cent deposit and raising a mortgage for the remainder.
Nationwide has been a prominent supporter of Government-backed schemes aimed at boosting the housing market.
Persimmon Homes' group communications director, Steve Roche, said: "Help To Buy has been hugely popular with prospective house buyers, as it enables people to secure the keys to their perfect home with a deposit of just 5 per cent.
"Since it was announced by the chancellor in this year's Budget statement, we have seen hundreds of new homes reserved using the Help To Buy scheme across our Persimmon Homes and Charles Church developments nationwide, and we expect the greater availability of mortgages through the scheme will maintain its popularity.
"The news that Nationwide - one of the biggest lenders in the market - is now able to offer its mortgage products for this shared equity scheme will certainly prove a boost for buyers, giving them a greater choice of lenders and helping to ensure competitive mortgage rates."
In 2012, Persimmon Group negotiated the legal completions of almost 10,000 new homes in England, Scotland and Wales. The company operates new developments under the Persimmon Homes, Charles Church, Westbury Partnerships brands, and at the time of publication, Hillreed Homes.
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